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The aging process affects us in various ways.  Just as a human ages, our skin cells are also biologically aging. 1  Reproduction of skin cells in the epidermis becomes sluggish over time, resulting in a deterioration of skin’s structure and its ability to function as optimally as it once did. 2  As hormone levels decline, skin can feel and look dry and dehydrated and you may notice laxity – loose, slacking skin – as well as textural changes. 3  The most consistent structural change in aged skin is a flattening of the EDJ (“Grenz Zone” ) by more than a third. 4-6 

According to the American Academy of Dermatology, hormonal aging may also contribute to an uneven skin tone, as well as fine lines and wrinkles due to diminished collagen production; 7  and skin may appear thinner due to a reduction in estrogen levels. 8  Vivier is proud to pioneer an extraordinary solution for hormonally aged, thinning skin.  GrenzCine with Polyamine-DAB™ is the first multi-layer and multi-function slow release anti-aging line resulting in beautiful, more luminous, plumper and healthier-looking skin using the power of polyamines; a naturally occurring molecule in the skin, essential for the growth and function of normal cells. 9  With more and more research, it has been shown that polyamines are involved in vital cellular processes. 10  Polyamines have been shown to help protect against free radical damage 10-11  and reduce the harmful effects of inflammation. 12  GrenzCine with Polyamine-DAB™ helps boosts fibrillar collagen, while healing and repairing (thickening) the skin and encouraging skin cell dynamics that help thicken and strengthen our Grenz Zone and epidermis. 13  By introducing topical polyamines to mature skin, we increase the efficiency of our cellular processes, 14  helping to bring our skin back to a healthier and more youthful looking state. 

GrenzCine with Polyamine-DAB™ is a powerful solution to address fine-lines, wrinkles, crepiness, and skin that has lost luminosity and volume due to aging, hormone levels and intrinsic/extrinsic factors. 

Consult your local practitioner to find out if GrenzCine is right for you!

GrenzCine Sērum  

Luxurious serum formulated to help increase the firmness, hydration and volume of your skin while diminishing the appearance of fine lines and wrinkles, increasing skin luminosity and improving skin tone, texture and elasticity.
 
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GrenzCine Eye

Luxurious eye cream specially formulated for the thin skin on the eyelids and around the eyes. Helps to increase the volume and firmness of the skin while diminishing the appearance of fine lines and wrinkles.
 
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GrenzCine Neck

Advanced neck treatment specially formulated for the thin, sagging skin on the neck. Provides anti-aging benefits of adding volume, brightening and moisturizing your skin.
 
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GrenzCine Body

Pearlescent moisturizing body treatment formulated to help increase the firmness and luminosity of the skin and improve its tone, texture and elasticity.
 
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By Perri Lomax

A Vivier Skin Care Expert.
Ask Perri  

      References:
      1. Farage, Miranda A et al. “Characteristics of the Aging Skin.” Advances in wound care vol. 2,1 (2013): 5-10. doi:10.1089/wound.2011.0356
      2. Glogau RG. Systemic evaluation of the aging face. In: Bolognia JL, editor; Jorizzo JL, editor; Rapini RP, editor. Dermatology. Edinburgh: Mosby; 2003. pp. 2357–2360 
      3. & 7-8.  “Caring for Your Skin in Menopause.” Caring for Your Skin in Menopause | American Academy of Dermatology, www.aad.org/public/skin-hair-nails/skin-care/skin-care-during-menopause 
      4. Martini F. Fundamentals of Anatomy and Physiology. San Francisco: Benjamin-Cummings; 2004.
      5. Südel KM. Venzke K. Mielke H. Breitenbach U. Mundt C. Jaspers S. Koop U. Sauermann K. Knussman-Hartig E. Moll I. Gercken G. Young AR. Stäb F. Wenck H. Gallinat S. Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. Photochem Photobiol. 2005;81:581.
      6. Neerken S. Lucassen GW. Bisschop MA. Lenderink E. Nuijs TAM. Characterization of age-related effects in human skin: a comparative study that applies confocal laser scanning microscopy and optical coherence tomography. J Biomed Opt. 2004; 9:274.
      9. Wallace, Heather & V Fraser, Alison & Hughes, Alun. (2003). A perspective of polyamine metabolism. The Biochemical journal. 376. 1-14. 10.1042/BJ20031327
      10. Minois N, Carmona-Gutierrez D, Madeo F. Polyamines in aging and disease. Aging (Albany NY). 2011;3(8):716-32.
      11. Minois N: Molecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review. Gerontology 2014; 60:319-326. doi:10. 1159/000356748
      12. Murray-Stewart, Tracy & T. Dunston, Tiffany & Woster, Patrick & Casero, Robert. (2018). Polyamine catabolism and oxidative damage. Journal of Biological Chemistry. 293. jbc.TM118.003337. 10.1074/jbc.TM118.003337.
      13. Marko Pietilä, Jyrki J. Parkkinen, Leena Alhonen, and Juhani Jänne, Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase, Journal of Investigative Dermatology Volume 116, Issue 5, May 2001, Pages 801-805
      14. Handa, Avtar K et al. “Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease” Frontiers in chemistry vol. 6 10. 5 Feb. 2018, doi:10.3389/fchem.2018.00010  

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